Topical Formulation Based on Arnebia euchroma as a Novel Possible Efficient Treatment on Epidermolysis Bullosa Lesions: A Case Series of Fourteen Patients

BACKGROUND: Epidermolysis bullosa (EB) is a skin fragility disorder that results in the disruption of dermo-epidermal junction and painful blisters on mucous membranes. Currently, there almost no definite treatment for EB patients. AIM: This study aims to assess effect topical formulation based Arnebia euchroma (AE) lesions induced by EB. MATERIALS AND METHODS: All patients with diseases treated Hochobeh ointment (AE+Beewax+Olive oil) 2022 at our dermatological clinic were included study. diagnosed following criteria: (1) clinical features (2) histopathological findings (3) Linear depositions IgG, IgA, IgM 4. salt-split (SSS) or other immune serological tests compatible diagnosis disease. lotion initiated. Clinical evaluations repeated 3 7 days after began, photographs taken document changes severity. Disease Activity Scarring Index (EBDASI) Quality Life (EB-QoL) questionnaires used severity quality life, respectively. statistical analyses performed using package social sciences version 16. RESULTS: Overall, fourteen included. Improvement features, including reduction infection inflammation improvement wound healing, was observed. EBDASI EB-QoL scores decreased significantly (91.5 ± 45.7 vs. 68.9 43, p = 0.001; 24.6 6.7 18 5.2, 0.001, respectively). CONCLUSION: may be effective treating mucosal lesions.